Séminaire thématique BIS2 - Atlas single-cell et méthodes de déconvolution : leçons apprises et défis - Amphitheâtre - Centre De Lutte Contre Le Cancer Eugène Marquis

PROGRAM

9:00 - 9:10 | Introduction
IGDR
9:10 - 9:40 Lucie Lamothe (Invited speaker, UGA UMR 5217, LIG, Grenoble)

• “A consensus-driven framework for building and sharing single-cell atlases applied to pancreatic ductal adenocarcinoma”

9:40 - 9:55 Luna Devemy (IGDR / Institut du Thorax, Nantes)

• “Understanding the protective effects of oleic acid in obese mice through single-nucleus reference-based deconvolution”

Institut Agro - PEGASE, INRAE
9:55 - 10:10 Fabien Degalez

• “Generation of a single-nucleus atlas of the adult chicken liver: impact of genome annotations and resolution approaches”

10:10 - 10:25 Guillaume Cossard

• “Single-cell guided deconvolution of RNAseq data from liver tissue of egg-laying hens: optimisation with benchmark data”

10:30 - 11:00 Coffee break

Oncogenesis, Stress & Signaling (OSS)
11:00 - 11:20 Flavie Benard (OMICs team, Inserm U1242, Université de Rennes)

• “Defining malignant cell states in glioblastoma by comparing gene signatures and scoring tools in published transcriptomics (single-cell and spatial) datasets”

MOBIDIC
11:20 - 11:50 Charles Brottier & Judikael Saout (Laboratoire SITI / Inserm U1236)

• “Deconvolution in Follicular Lymphoma : The Interplay Between Single-Cell References and Deconvolution Approaches”

11:50 - 12:10 Valentin Isen & Valeria Chahwan (Inserm U1236)

• “Integrating without erasing biological variations: how to build and transfer an atlas with strong batch effects”

12:10 - 12:15 Concluding remarks
Contact: Yuna Blum
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