Institut Pasteur, Paris
Immune defense mechanisms exist across the tree of life in such a wide diversity that the immune mechanisms of bacteria (antiphage systems) were considered unrelated to immunity of eukaryotes. However, recent discoveries unveiled hundreds of novel antiphage systems. Among this diversity of novel bacterial immune mechanisms, it emerged that a subset of antiphage defense systems is conserved in eukaryotes and are major actors of diverse immune pathways, leading us to revisit this paradigm and propose the concept of ancestral immunity as protein domains used in prokaryotic and eukaryotic immunity. I will discuss the evolutionary dynamics of immunity across domains of life and how existence of ancestral immunity can lead to discoveries in prokaryotes and eukaryotes.
L'organisation de ce séminaire est soutenu par la SFR B2S.
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