Gustave Roussy Institute, Villejuif, France
We investigate how mechanical parameters from the microenvironment such as rigidity and topology regulate the dynamics and functions of clathrin-coated structures (CCS). CCS are the support of clathrin-mediated endocytosis and their primary task is to pack receptors in clathrin-coated vesicles by bending the plasma membrane. Our work show that the topology, substrate elasticity and confinement impact the structure and functions of CCSs. We develop the concept of frustrated endocytose whereby CCS try and fail to internalize a piece of its environment. This can result in CCS pinching collagen fibers or tubular membranes and serving as adhesion points to these environmental cues. It can also lead to forming signaling platforms that instruct cell response to the substrate rigidity.
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