Functional Genomic Institute, Montpellier, France
Since cancer has been considered for ages as a disease of proliferation, identification of cancer stem cells has considerably changed this dogma. Cancer Stem Cells (CSC) represent a subpopulation of tumoral cells endowed with self-renewal, tumor initiation and resistance capacities. In the team we are focused on their signaling pathways and plasticity and we are studying more precisely their involvement in tumor recurrence in colorectal cancer. Our research is organized within 2 main axes. The first axis is focused on the deciphering of mechanisms explaining CSC chemoresistance in the aim of identifying innovative strategies to sensitize CSC to these drugs. The second axis proposes to study tumoral dissemination with a special focus on the circulating tumor cell characterization, early dissemination and tumor dormancy.
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