Prof. Drąg's research interests in chemical biology include the design and synthesis of substrates, inhibitors and activity-based probes to decipher the mechanism of action and the function of proteases in health and disease. Prof. Drąg described several new, versatile technologies useful for rapid determination of proteolytic enzyme substrate specificity. In particular, his laboratory has developed specialization in the application of a large number of unnatural amino acids in combinatorial library structures and the procedure called HyCoSuL (hybrid combinatorial substrate library) that combines natural (proteinogenic) and unnatural (non-proteinogenic) amino acids to enhance targeting affinity of peptides for proteases. He is an author of more than 100 publications in peer-reviewed scientific journals (f.e.: Nature Reviews Drug Discovery, Nature Chemical Biology, Nature Protocols, Chemical Reviews, Journal of the American Chemical Society, PNAS).
Source : Open Agenda